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Research ArticleRESEARCH PERSPECTIVES
Open Access

Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline

C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga and M.W. Vernooij
American Journal of Neuroradiology June 2015, DOI: https://doi.org/10.3174/ajnr.A4409
C.A. Raji
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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H. Eyre
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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S.H. Wei
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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D.E. Bredesen
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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S. Moylan
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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M. Law
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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G. Small
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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P.M. Thompson
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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R.M. Friedlander
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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D.H. Silverman
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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B.T. Baune
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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T.A. Hoang
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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N. Salamon
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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A.W. Toga
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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M.W. Vernooij
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
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Abstract

SUMMARY: Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.

Abbreviations

AD
Alzheimer disease
APOE
Apolipoprotein E
BMI
body mass index
MCI
mild cognitive impairment
  • © 2015 American Society of Neuroradiology

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Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409

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Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409
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