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Research ArticleADULT BRAIN
Open Access

Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis

R. Zivadinov, B. Raj, M. Ramanathan, B. Teter, J. Durfee, M.G. Dwyer, N. Bergsland, C. Kolb, D. Hojnacki, R.H. Benedict and B. Weinstock-Guttman
American Journal of Neuroradiology February 2016, DOI: https://doi.org/10.3174/ajnr.A4681
R. Zivadinov
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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B. Raj
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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M. Ramanathan
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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B. Teter
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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J. Durfee
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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M.G. Dwyer
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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N. Bergsland
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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C. Kolb
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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D. Hojnacki
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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R.H. Benedict
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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B. Weinstock-Guttman
From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A4681
PubMed 
26892983

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Published online February 18, 2016.

Article Versions

  • You are currently viewing a Latest version of this article (February 18, 2016 - 07:06).
  • View the most recent version of this article
Copyright & Usage 
© 2016 American Society of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. R. Zivadinov,
  2. B. Raj,
  3. M. Ramanathan,
  4. B. Teter,
  5. J. Durfee,
  6. M.G. Dwyer,
  7. N. Bergsland,
  8. C. Kolb,
  9. D. Hojnacki,
  10. R.H. Benedict and
  11. B. Weinstock-Guttman
  1. From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo Neuroimaging Analysis Center, and Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center, University at Buffalo, State University of New York, Buffalo, New York; MR Imaging Clinical Translational Research Center (R.Z.) and Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York; and Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy.
  1. Please address correspondence to Robert Zivadinov, MD, PhD, Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, School of Medicine and Biomedical Sciences, 100 High St, Buffalo, NY 14203; e-mail: rzivadinov{at}bnac.net

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Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis
R. Zivadinov, B. Raj, M. Ramanathan, B. Teter, J. Durfee, M.G. Dwyer, N. Bergsland, C. Kolb, D. Hojnacki, R.H. Benedict, B. Weinstock-Guttman
American Journal of Neuroradiology Feb 2016, DOI: 10.3174/ajnr.A4681

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Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis
R. Zivadinov, B. Raj, M. Ramanathan, B. Teter, J. Durfee, M.G. Dwyer, N. Bergsland, C. Kolb, D. Hojnacki, R.H. Benedict, B. Weinstock-Guttman
American Journal of Neuroradiology Feb 2016, DOI: 10.3174/ajnr.A4681
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