Research ArticlePEDIATRICS
In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI
L. Václavů, V. van der Land, D.F.R. Heijtel, M.J.P. van Osch, M.H. Cnossen, C.B.L.M. Majoie, A. Bush, J.C. Wood, K.J. Fijnvandraat, H.J.M.M. Mutsaerts and A.J. Nederveen
American Journal of Neuroradiology May 2016, DOI: https://doi.org/10.3174/ajnr.A4793
L. Václavů
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
V. van der Land
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
D.F.R. Heijtel
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
M.J.P. van Osch
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
M.H. Cnossen
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
C.B.L.M. Majoie
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
A. Bush
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
J.C. Wood
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
K.J. Fijnvandraat
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
H.J.M.M. Mutsaerts
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
A.J. Nederveen
From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
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- Published online May 26, 2016.
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© 2016 American Society of Neuroradiology
Author Information
- L. Václavů,
- V. van der Land,
- D.F.R. Heijtel,
- M.J.P. van Osch,
- M.H. Cnossen,
- C.B.L.M. Majoie,
- A. Bush,
- J.C. Wood,
- K.J. Fijnvandraat,
- H.J.M.M. Mutsaerts and
- A.J. Nederveen
- From the Department of Radiology (L.V., D.F.R.H., C.B.L.M.M., H.J.M.M.M., A.J.N.), Academic Medical Center, Amsterdam, the Netherlands; Department of Pediatric Hematology (V.v.d.L., K.J.F.), Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands; C.J. Gorter Center for High Field MRI (M.J.P.v.O.), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatric Hematology (M.H.C.), Erasmus University Medical Center–Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Biomedical Engineering (A.B.), Viterbi School of Engineering, University of Southern California, Los Angeles, California; Department of Pediatrics (J.C.W.), Children's Hospital Los Angeles, Los Angeles, California; and Sunnybrook Research Institute (H.J.M.M.M.), Toronto, Ontario, Canada.
- Please address correspondence to Lena Václavů, MSc, Department of Radiology, Z0-178, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands; e-mail: l.vaclavu{at}amc.uva.nl
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In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI
L. Václavů, V. van der Land, D.F.R. Heijtel, M.J.P. van Osch, M.H. Cnossen, C.B.L.M. Majoie, A. Bush, J.C. Wood, K.J. Fijnvandraat, H.J.M.M. Mutsaerts, A.J. Nederveen
American Journal of Neuroradiology May 2016, DOI: 10.3174/ajnr.A4793
In Vivo T1 of Blood Measurements in Children with Sickle Cell Disease Improve Cerebral Blood Flow Quantification from Arterial Spin-Labeling MRI
L. Václavů, V. van der Land, D.F.R. Heijtel, M.J.P. van Osch, M.H. Cnossen, C.B.L.M. Majoie, A. Bush, J.C. Wood, K.J. Fijnvandraat, H.J.M.M. Mutsaerts, A.J. Nederveen
American Journal of Neuroradiology May 2016, DOI: 10.3174/ajnr.A4793
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