Early Biomarkers from Conventional and Delayed-Contrast MRI to Predict the Response to Bevacizumab in Recurrent High-Grade Gliomas

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

From the Oncology Institute (L.Z., A.T.), Advanced Technology Center (D.G., D.L., D.D., S.S., Y.M.), Department of Neurosurgery (Z.R.C., S.H.), Radiology Institute (C.H., G.T.), and Pathology Institute (D.N.), Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine (L.Z., D.D., C.H., G.T., Z.R.C., Y.M., S.H.) and School of Mathematical Sciences (D.Y., S.Z.), Tel-Aviv University, Tel-Aviv, Israel; and Neuro- Oncology Service (D.T.B., F.B.) and Stereotactic Radiosurgery Unit (A.A.K.), Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.