Abstract
SUMMARY: Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.
ABBREVIATIONS:
- BBB
- blood-brain barrier
- pc
- postcontrast
Footnotes
Whitney M. Freeze and David N. ter Weele contributed equally to this work.
Disclosures: Whitney M. Freeze—RELATED: Grant: Alzheimer Nederland and Stichting 2Bike4Alzheimer, Comments: Costs related to data acquisition and part of my (regular) salary were covered by Alzheimer Nederland and Stichting 2Bike4Alzheimer (research grant WE-03-2012-40).* Roy W. van Hooren—RELATED: Alzheimer Nederland (research grant WE-03-2012-40), Comments: Part of my salary enabling my work for this project was funded by this grant*; UNRELATED: Employment: Maastricht University, Comments: The rest of my salary was paid by Maastricht University. Heidi I.L. Jacobs—RELATED: Grant: Alzheimer Nederland, Comments: This research was supported by Alzheimer Nederland (research grant WE-03-2012-40)*; Support for Travel to Meetings for the Study or Other Purposes: Alzheimer Nederland, Comments: Dr Freeze was supported by Alzheimer Nederland to present this work July 14–18, 2019 at Alzheimer's Association International Conference.* Frans R. Verhey—UNRELATED: Grants/Grants Pending: European Commission, Comments: Dementia: Intersectorial Strategy for Training and Innovation Network for Current Technology, Marie Curie H2020 Innovative Training Network.* *Money paid to institution.
This research was supported by Alzheimer Nederland and Stichting 2Bike4Alzheimer (research grant WE-03-2012-40).
Paper previously presented, in part, at: Annual Meeting of NVKF Lustrumcongres, April 4–5, 2019; Woudschoten, the Netherlands.
- © 2019 by American Journal of Neuroradiology