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Research ArticlePEDIATRICS

The Perirolandic Sign: A Unique Imaging Finding Observed in Association with Polymerase γ-Related Disorders

F.G. Gonçalves, B. Hill, Y. Guo, C.C. Muraresku, E. McCormick, C.A.P.F. Alves, S.R. Teixeira, J.S. Martin-Saavedra, Z. Zolkipli-Cunningham, M.J. Falk, A. Vossough, A. Goldstein and G. Zuccoli
American Journal of Neuroradiology May 2020, DOI: https://doi.org/10.3174/ajnr.A6514
F.G. Gonçalves
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
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  • ORCID record for F.G. Gonçalves
B. Hill
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
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Y. Guo
cDepartments of Pediatrics (Y.G., Z.Z.-C., M.J.F., A.G.)
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C.C. Muraresku
bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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E. McCormick
bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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C.A.P.F. Alves
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
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S.R. Teixeira
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
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J.S. Martin-Saavedra
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
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Z. Zolkipli-Cunningham
bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
cDepartments of Pediatrics (Y.G., Z.Z.-C., M.J.F., A.G.)
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M.J. Falk
bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
cDepartments of Pediatrics (Y.G., Z.Z.-C., M.J.F., A.G.)
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A. Vossough
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
dRadiology (A.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
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A. Goldstein
bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
cDepartments of Pediatrics (Y.G., Z.Z.-C., M.J.F., A.G.)
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G. Zuccoli
aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
eThe Program for the Study of Neurodevelopment in Rare Disorders (NDRD) (G.Z.), Children's Hospital of Pittsburgh of UPMC.
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A6514
PubMed 
32381541

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received December 18, 2019
  • Accepted after revision February 27, 2020
  • Published online May 7, 2020.

Article Versions

  • You are currently viewing a Latest version of this article (May 7, 2020 - 06:40).
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Copyright & Usage 
© 2020 by American Journal of Neuroradiology

Author Information

  1. F.G. Gonçalvesa,
  2. B. Hilla,
  3. Y. Guoc,
  4. C.C. Murareskub,
  5. E. McCormickb,
  6. C.A.P.F. Alvesa,
  7. S.R. Teixeiraa,
  8. J.S. Martin-Saavedraa,
  9. Z. Zolkipli-Cunninghamb,c,
  10. M.J. Falkb,c,
  11. A. Vossougha,d,
  12. A. Goldsteinb,c and
  13. G. Zuccolia,e
  1. aFrom the Departments of Radiology and Division of Neuroradiology (F.G.G., B.H., C.A.P.F.A., S.R.T., J.S.M.-S., A.V., G.Z.)
  2. bMitochondrial Medicine Frontier Program, Division of Human Genetics (C.C.M., E.M., Z.Z.-C., M.J.F., A.G.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  3. cDepartments of Pediatrics (Y.G., Z.Z.-C., M.J.F., A.G.)
  4. dRadiology (A.V.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  5. eThe Program for the Study of Neurodevelopment in Rare Disorders (NDRD) (G.Z.), Children's Hospital of Pittsburgh of UPMC.
  1. Please address correspondence to Fabrício Guimarães Gonçalves, MD, Department of Radiology and Division of Neuroradiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104; e-mail: goncalves.neuroradio{at}gmail.com; @Fab_Neuroradio
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Funding

  • This work was funded in part by the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia.

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The Perirolandic Sign: A Unique Imaging Finding Observed in Association with Polymerase γ-Related Disorders
F.G. Gonçalves, B. Hill, Y. Guo, C.C. Muraresku, E. McCormick, C.A.P.F. Alves, S.R. Teixeira, J.S. Martin-Saavedra, Z. Zolkipli-Cunningham, M.J. Falk, A. Vossough, A. Goldstein, G. Zuccoli
American Journal of Neuroradiology May 2020, DOI: 10.3174/ajnr.A6514

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The Perirolandic Sign: A Unique Imaging Finding Observed in Association with Polymerase γ-Related Disorders
F.G. Gonçalves, B. Hill, Y. Guo, C.C. Muraresku, E. McCormick, C.A.P.F. Alves, S.R. Teixeira, J.S. Martin-Saavedra, Z. Zolkipli-Cunningham, M.J. Falk, A. Vossough, A. Goldstein, G. Zuccoli
American Journal of Neuroradiology May 2020, DOI: 10.3174/ajnr.A6514
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