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Research ArticlePEDIATRICS

Diffuse Leptomeningeal Glioneuronal Tumor of Childhood

D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma and S. Pruthi
American Journal of Neuroradiology September 2020, DOI: https://doi.org/10.3174/ajnr.A6737
D.A. Lakhani
aFrom the Department of Radiology (D.A.L., P.F.), School of Medicine, West Virginia University, Morgantown, West Virginia
bDepartment of Neuroradiology (D.A.L., P.F.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia
cDivision of Internal Medicine (D.A.L.), Vanderbilt University Medical Center, Nashville, Tennessee
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K. Mankad
dDepartment of Neuroradiology (K.M., S.C.), Great Ormond Street Hospital (GOSH), London, UK
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S. Chhabda
dDepartment of Neuroradiology (K.M., S.C.), Great Ormond Street Hospital (GOSH), London, UK
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P. Feizi
aFrom the Department of Radiology (D.A.L., P.F.), School of Medicine, West Virginia University, Morgantown, West Virginia
bDepartment of Neuroradiology (D.A.L., P.F.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia
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R. Patel
eDepartment of Diagnostic and Interventional Imaging, Section of Neuroradiology (R.P.), The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas
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A. Sarma
fDepartment of Radiology and Radiological Sciences (A.S., S.P.), Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee.
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S. Pruthi
fDepartment of Radiology and Radiological Sciences (A.S., S.P.), Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee.
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Abstract

SUMMARY: Diffuse leptomeningeal glioneuronal tumor is a newly defined entity under the neuronal and mixed neuronal-glial tumors category in the 2016 World Health Organization classification of brain tumors. In this series, we report clinical, radiologic, and histologic findings in 7 cases of diffuse leptomeningeal glioneuronal tumor. Our cases and literature review indicate that the most characteristic imaging finding is diffuse intracranial and intraspinal nodular leptomeningeal thickening and enhancement. This is often associated with small cyst-like, nonenhancing lesions. It should be noted that tumors sometimes bear nontypical features, for example, presenting as a solitary spinal cord mass without leptomeningeal involvement or with a dominant intracranial mass. In children with characteristic imaging findings and without clinical features of infection, the radiologist has an opportunity to promptly raise the possibility of diffuse leptomeningeal glioneuronal tumor, and thereby, affect streamlined diagnostic evaluation.

ABBREVIATIONS:

DL-GNT
diffuse leptomeningeal glioneuronal tumor
WHO
World Health Organization

Footnotes

  • Previously presented in part at: Annual Meeting of the American Society of Pediatric Neuroradiology 2019, January 18–21; Los Angeles, California.

  • Disclosures: Kshitij Mankad—UNRELATED: Expert Testimony: Medicolegal reporting in UK; Payment for Lectures Including Service on Speakers Bureaus: Speaker honoraria – Novartis, Siemens. Asha Sarma—UNRELATED: Royalties: Cambridge University Press, Comments: Unrelated textbook.

  • © 2020 by American Journal of Neuroradiology
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Diffuse Leptomeningeal Glioneuronal Tumor of Childhood
D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma, S. Pruthi
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6737

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Diffuse Leptomeningeal Glioneuronal Tumor of Childhood
D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma, S. Pruthi
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6737
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