This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Abstract
SUMMARY: Diffuse leptomeningeal glioneuronal tumor is a newly defined entity under the neuronal and mixed neuronal-glial tumors category in the 2016 World Health Organization classification of brain tumors. In this series, we report clinical, radiologic, and histologic findings in 7 cases of diffuse leptomeningeal glioneuronal tumor. Our cases and literature review indicate that the most characteristic imaging finding is diffuse intracranial and intraspinal nodular leptomeningeal thickening and enhancement. This is often associated with small cyst-like, nonenhancing lesions. It should be noted that tumors sometimes bear nontypical features, for example, presenting as a solitary spinal cord mass without leptomeningeal involvement or with a dominant intracranial mass. In children with characteristic imaging findings and without clinical features of infection, the radiologist has an opportunity to promptly raise the possibility of diffuse leptomeningeal glioneuronal tumor, and thereby, affect streamlined diagnostic evaluation.
ABBREVIATIONS:
- DL-GNT
- diffuse leptomeningeal glioneuronal tumor
- WHO
- World Health Organization
Footnotes
Previously presented in part at: Annual Meeting of the American Society of Pediatric Neuroradiology 2019, January 18–21; Los Angeles, California.
Disclosures: Kshitij Mankad—UNRELATED: Expert Testimony: Medicolegal reporting in UK; Payment for Lectures Including Service on Speakers Bureaus: Speaker honoraria – Novartis, Siemens. Asha Sarma—UNRELATED: Royalties: Cambridge University Press, Comments: Unrelated textbook.
- © 2020 by American Journal of Neuroradiology