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Research ArticlePEDIATRICS
Open Access

Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain

S.K. Basu, S. Pradhan, S.D. Barnett, M. Mikkelsen, K.J. Kapse, J. Murnick, J.L. Quistorff, C.A. Lopez, A.J. du Plessis and C. Limperopoulos
American Journal of Neuroradiology November 2021, DOI: https://doi.org/10.3174/ajnr.A7336
S.K. Basu
aFrom the Department of Neonatology (S.K.B.)
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
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S. Pradhan
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
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S.D. Barnett
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
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M. Mikkelsen
fDepartment of Radiology (M.M., J.M.), Weill Cornell Medicine, New York, New York
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K.J. Kapse
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
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J. Murnick
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
fDepartment of Radiology (M.M., J.M.), Weill Cornell Medicine, New York, New York
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J.L. Quistorff
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
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C.A. Lopez
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
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A.J. du Plessis
dFetal Medicine Institute (A.J.d.P.), Children’s National Hospital, Washington, DC
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
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C. Limperopoulos
bDeveloping Brain Institute (S.K.B., S.P., S.D.B., K.J.K., J.L.Q., C.A.L., C.L.)
cDivision of Diagnostic Imaging and Radiology (C.L.)
eGeorge Washington University School of Medicine (S.K.B. S.P., S.D.B., J.M., A.J.d.P., C.L.), Washington, DC
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References

  1. 1.↵
    1. Volpe JJ
    . Volpe’s Neurology of the Newborn. Elsevier; 2018
  2. 2.↵
    1. Robinson S,
    2. Li Q,
    3. Dechant A, et al
    . Neonatal loss of gamma-aminobutyric acid pathway expression after human perinatal brain injury. J Neurosurg 2006;104(6 Suppl):396–408 doi:10.3171/ped.2006.104.6.396 pmid:16776375
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Shaw JC,
    2. Palliser HK,
    3. Dyson RM, et al
    . Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth. Int J Dev Neurosci 2018;65:1–10 doi:10.1016/j.ijdevneu.2017.10.002 pmid:29024720
    CrossRefPubMed
  4. 4.↵
    1. Laptook AR,
    2. O'Shea TM,
    3. Shankaran S, et al
    . Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics 2005;115:673–80 doi:10.1542/peds.2004-0667 pmid:15741371
    Abstract/FREE Full Text
  5. 5.↵
    1. Harris AD,
    2. Saleh MG,
    3. Edden RA
    . Edited 1H-magnetic resonance spectroscopy in vivo: methods and metabolites. Magn Reson Med 2017;77:1377–89 doi:10.1002/mrm.26619 pmid:28150876
    CrossRefPubMed
  6. 6.↵
    1. Mullins PG,
    2. McGonigle DJ,
    3. O’Gorman RL, et al
    .; Cardiff Symposium on MRS of GABA. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. Neuroimage 2014;86:43–52 doi:10.1016/j.neuroimage.2012.12.004 pmid:23246994
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Basu SK,
    2. Pradhan S,
    3. Jacobs MB, et al
    . Age and sex influences gamma-aminobutyric acid concentrations in the developing brain of very premature infants. Sci Rep 2020;10:10549 doi:10.1038/s41598-020-67188-y pmid:32601466
    CrossRefPubMed
  8. 8.↵
    1. Maria YL,
    2. Price AN,
    3. Puts NA, et al
    . Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy. Neuroimage 2021;233:117930 doi:10.1016/j.neuroimage.2021.117930 pmid:33711485
    CrossRefPubMed
  9. 9.↵
    1. Kwon SH,
    2. Scheinost D,
    3. Lacadie C, et al
    . GABA, resting-state connectivity and the developing brain. Neonatology 2014;106:149–55 doi:10.1159/000362433 pmid:24970028
    CrossRefPubMed
  10. 10.↵
    1. Tomiyasu M,
    2. Aida N,
    3. Shibasaki J, et al
    . In vivo estimation of gamma-aminobutyric acid levels in the neonatal brain. NMR Biomed 2017;30:e3666 doi:10.1002/nbm.3666 pmid:27859844
    CrossRefPubMed
  11. 11.↵
    1. Basu SK,
    2. Pradhan S,
    3. Du Plessis AJ, et al
    . GABA and glutamate in the preterm neonatal brain: in-vivo measurement by magnetic resonance spectroscopy. Neuroimage 2021;238:118215 doi:10.1016/j.neuroimage.2021.118215 pmid:34058332
    CrossRefPubMed
  12. 12.↵
    1. Xu G,
    2. Broadbelt KG,
    3. Haynes RL, et al
    . Late development of the GABAergic system in the human cerebral cortex and white matter. J Neuropathol Exp Neurol 2011;70:841–58 doi:10.1097/NEN.0b013e31822f471c pmid:21937910
    CrossRefPubMed
  13. 13.↵
    1. Tkac I,
    2. Rao R,
    3. Georgieff MK, et al
    . Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy. Magn Reson Med 2003;50:24–32 doi:10.1002/mrm.10497 pmid:12815675
    CrossRefPubMed
  14. 14.↵
    1. O'Gorman RL,
    2. Michels L,
    3. Edden RA, et al
    . In vivo detection of GABA and glutamate with MEGA-PRESS: reproducibility and gender effects. J Magn Reson Imaging 2011;33:1262–67 doi:10.1002/jmri.22520 pmid:21509888
    CrossRefPubMed
  15. 15.↵
    1. Castillo-Ruiz A,
    2. Mosley M,
    3. Jacobs AJ, et al
    . Birth delivery mode alters perinatal cell death in the mouse brain. Proc Natl Acad Sci U S A 2018;115:11826–31 doi:10.1073/pnas.1811962115 pmid:30322936
    Abstract/FREE Full Text
  16. 16.↵
    1. Ramu J,
    2. Konak T,
    3. Liachenko S
    . Magnetic resonance spectroscopic analysis of neurometabolite changes in the developing rat brain at 7T. Brain Res 2016;1651:114–20 doi:10.1016/j.brainres.2016.09.028 pmid:27663970
    CrossRefPubMed
  17. 17.↵
    1. Koob M,
    2. Viola A,
    3. Le Fur Y, et al
    . Creatine, glutamine plus glutamate, and macromolecules are decreased in the central white matter of premature neonates around term. PLoS One 2016;11:e0160990 doi:10.1371/journal.pone.0160990 pmid:27547969
    CrossRefPubMed
  18. 18.↵
    1. Basu SK,
    2. Pradhan S,
    3. Kapse K, et al
    . Third trimester cerebellar metabolite concentrations are decreased in very premature infants with structural brain injury. Sci Rep 2019;9:1212–14 doi:10.1038/s41598-018-37203-4 pmid:30718546
    CrossRefPubMed
  19. 19.↵
    1. Tanifuji S,
    2. Akasaka M,
    3. Kamei A, et al
    . Temporal brain metabolite changes in preterm infants with normal development. Brain Dev 2017;39:196–202 doi:10.1016/j.braindev.2016.10.006 pmid:27838187
    CrossRefPubMed
  20. 20.↵
    1. Craddock RC,
    2. James GA,
    3. Holtzheimer PE, et al
    . A whole brain fMRI atlas generated via spatially constrained spectral clustering. Hum Brain Mapp 2012;33:1914–28 doi:10.1002/hbm.21333 pmid:21769991
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Evangelou IE,
    2. Noeske R,
    3. Limperopoulos C
    . Retrospective correction of motion induced artifacts in 1H magnetic resonance spectroscopy of the fetal brain. In: Proceedings of the IEEE 12th International Symposium on Biomedical Imaging (ISBI), Brooklyn, New York, USA. April 16–19, 2015:853–57
  22. 22.↵
    1. Provencher SW
    . Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001;14:260–64 doi:10.1002/nbm.698 pmid:11410943
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Kreis R
    . The trouble with quality filtering based on relative Cramer-Rao lower bounds. Magn Reson Med 2016;75:15–18 doi:10.1002/mrm.25568 pmid:25753153
    CrossRefPubMed
  24. 24.↵
    1. Wilson M,
    2. Andronesi O,
    3. Barker PB, et al
    . Methodological consensus on clinical proton MRS of the brain: review and recommendations. Magn Reson Med 2019;82:527–50 doi:10.1002/mrm.27742 pmid:30919510
    CrossRefPubMed
  25. 25.↵
    1. Edden RA,
    2. Puts NA,
    3. Harris AD, et al
    . Gannet: a batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra. J Magn Reson Imaging 2014;40:1445–52 doi:10.1002/jmri.24478 pmid:25548816
    CrossRefPubMed
  26. 26.↵
    1. Lin A,
    2. Andronesi O,
    3. Bogner W, et al
    ; Experts’ Working Group on Reporting Standards for MR Spectroscopy. Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): experts’ consensus recommendations. NMR Biomed 2021;34;e4484 doi:10.1002/nbm.4484 pmid:33559967
    CrossRefPubMed
  27. 27.↵
    1. Choi IY,
    2. Andronesi OC,
    3. Barker P, et al
    . Spectral editing in 1H-magnetic resonance spectroscopy: experts’ consensus recommendations. NMR Biomed 2021;34:e4411 doi:10.1002/nbm.4411 pmid:32946145
    CrossRefPubMed
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Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain
S.K. Basu, S. Pradhan, S.D. Barnett, M. Mikkelsen, K.J. Kapse, J. Murnick, J.L. Quistorff, C.A. Lopez, A.J. du Plessis, C. Limperopoulos
American Journal of Neuroradiology Nov 2021, DOI: 10.3174/ajnr.A7336

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Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain
S.K. Basu, S. Pradhan, S.D. Barnett, M. Mikkelsen, K.J. Kapse, J. Murnick, J.L. Quistorff, C.A. Lopez, A.J. du Plessis, C. Limperopoulos
American Journal of Neuroradiology Nov 2021, DOI: 10.3174/ajnr.A7336
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