Section Editor: Sandy Cheng-Yu Chen, M.D.
Taipei Medical University Hospital, Taipei, Taiwan
Figure Caption
Neurofibromatosis Type II (NF-2) is an autosomal dominant inherited disease, otherwise known as MISME syndrome—for Multiple Inherited Schwannomas, Meningiomas, and Ependymomas. This classic case illustrates multiple calcified meningiomas and a cervical spine ependymoma (arrow in quiz image), which both avidly enhance on gadolinium post-contrast imaging. Classic imaging findings also include bilateral vestibular schwannomas (not shown). Two phenotypes have been characterized in NF-2: Wishart-Phenotype are patients younger than 20 that have multiple cerebral and spinal lesions with rapid progression of the tumors, while patients who develop single central tumors with slow progression after the age of 20 are believed to have the Feiling-Gardner-Phenotype.