Section Editor: Sandy Cheng-Yu Chen, M.D.
Taipei Medical University Hospital, Taipei, Taiwan
Figure Caption
Frontotemporal dementia (FTD) is a type of degenerative dementia characterized by marked atrophy of the frontal and temporal lobe. Most FTD occurs in patients in their 50s and early 60s. The classic MRI findings include a characteristic anteroposterior gradient of cortical atrophy (yellow arrows), often asymetric, and associated with FLAIR hyperintensities (white arrows), possibly due to increased astrocytic gliosis. In the behavioral variant of FTD, marked behavioral changes and frontal syndrome are typical, and the atrophy predominates in the frontal regions. Accompanied atrophy of the caudate nuclei is likely due to the impaired frontal efferent and afferent loops (green arrows).