RT Journal Article
SR Electronic
T1 Amino Acid Tracer PET MRI in Glioma Management: What a Neuroradiologist Needs to Know
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A7762
A1 N. Soni
A1 M. Ora
A1 A. Jena
A1 P. Rana
A1 R. Mangla
A1 S. Ellika
A1 J. Almast
A1 S. Puri
A1 S.P. Meyers
YR 2023
UL http://www.ajnr.org/content/early/2023/01/19/ajnr.A7762.abstract
AB SUMMARY: PET with amino acid tracers provides additional insight beyond MR imaging into the biology of gliomas that can be used for initial diagnosis, delineation of tumor margins, planning of surgical and radiation therapy, assessment of residual tumor, and evaluation of posttreatment response. Hybrid PET MR imaging allows the simultaneous acquisition of various PET and MR imaging parameters in a single investigation with reduced scanning time and improved anatomic localization. This review aimed to provide neuroradiologists with a concise overview of the various amino acid tracers and a practical understanding of the clinical applications of amino acid PET MR imaging in glioma management. Future perspectives in newer advances, novel radiotracers, radiomics, and cost-effectiveness are also outlined.AATamino acid tracerAAamino acidASCTalanine-serine-cysteine transporterBTVbiologic tumor volumeGBMglioblastoma multiformeFDOPA3,4-dihydroxy-6-[18F]fluoro-L-phenylalanineFETO-(2-[18F]fluoroethyl)-L-tyrosineLATlarge amino acid transporterHGGhigh-grade gliomaLGGlow-grade gliomaMET11C-methioninerCBVrelative CBVTACtime-activity curveTBRtumor-to-background ratioTRCtreatment-related changesTSPOtranslocator proteinWHOWorld Health Organization