TY - JOUR T1 - Prognostic Value of Subacute Crossed Cerebellar Diaschisis: Single-Photon Emission CT Study in Patients with Middle Cerebral Artery Territory Infarct JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 189 LP - 193 VL - 23 IS - 2 AU - Masashi Takasawa AU - Manabu Watanabe AU - Shiro Yamamoto AU - Taku Hoshi AU - Tsutomu Sasaki AU - Kazuo Hashikawa AU - Masayasu Matsumoto AU - Naokazu Kinoshita Y1 - 2002/02/01 UR - http://www.ajnr.org/content/23/2/189.abstract N2 - BACKGROUND AND PURPOSE: Although chronic-stage crossed cerebellar diaschisis (CCD) is reported to be associated with the neurologic state or clinical improvement after infarct, the prognostic value of early-stage CCD remains controversial. Our aim was to determine whether measurements of CCD in the acute and subacute stages obtained at single-photon emission CT (SPECT) facilitate the prediction of stroke outcome.METHODS: The pattern of cerebral blood flow changes after the occurrence of acute middle cerebral artery ischemia with severe cortical symptoms was examined by using technetium 99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT. Fifteen patients (mean age, 73 years ± 8 [SD]) with unilateral ischemia were examined in the early subacute stage (10 days ± 5). In 11 patients, SPECT was performed in both the acute (16 hours ± 10) and subacute stages. From the total counts obtained from each cerebellar hemisphere, the asymmetry index (AI) was calculated as follows: [(value in unaffected hemisphere − value in affected hemisphere)/value in unaffected hemisphere] × 100. Clinical outcome (at 60 days) was assessed by means of the Scandinavian Stroke Scale (SSS) and Barthel Index (BI).RESULTS: AIs in the acute stage and clinical outcome (ie, SSS and BI scores) showed no significant correlation, but the severity of AI in the early subacute stage correlated significantly with both the final SSS (r = −0.69; P < .01) and BI scores (r = −0.82; P < .01).CONCLUSION: Cerebellar hypoperfusion detected at 99mTc-HMPAO SPECT in the early subacute stage in patients with supratentorial infarct indicates a worse clinical outcome. ER -