PT  - JOURNAL ARTICLE
AU  - Kathleen J. Helton
AU  - Winfred C. Wang
AU  - Lynn W. Wynn
AU  - Raja B. Khan
AU  - R. Grant Steen
TI  - The Effect of Hydroxyurea on Vasculopathy in a Child with Sickle Cell Disease
DP  - 2002 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1692--1696
VI  - 23
IP  - 10
4099  - http://www.ajnr.org/content/23/10/1692.short
4100  - http://www.ajnr.org/content/23/10/1692.full
SO  - Am. J. Neuroradiol.2002 Nov 01; 23
AB  - Summary: We report serial CNS findings in a girl with sickle cell disease and stroke. Religious considerations precluded transfusion and bone marrow transplantation; therefore, she received single-agent hydroxyurea therapy for almost 6 years. MR angiography showed that vascular patency improved, although diffuse cerebral atrophy slowly worsened. Hydroxyurea can be effective in treating vasculopathy, but it might not prevent the progression of parenchymal damage in advanced disease.