TY - JOUR T1 - Reinterpretation of Cross-Sectional Images in Patients with Head and Neck Cancer in the Setting of a Multidisciplinary Cancer Center JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1622 LP - 1626 VL - 23 IS - 10 AU - Laurie A. Loevner AU - Adina I. Sonners AU - Brian J. Schulman AU - Kerstin Slawek AU - Randal S. Weber AU - David I. Rosenthal AU - Gul Moonis AU - Ara A. Chalian Y1 - 2002/11/01 UR - http://www.ajnr.org/content/23/10/1622.abstract N2 - BACKGROUND AND PURPOSE: Patients referred to tertiary care centers frequently arrive with images obtained at outside institutions; these images require reinterpretation. We assessed the clinical value of reinterpreting cross-sectional imaging studies of patients with head and neck cancer, in the setting of a multidisciplinary cancer center.METHODS: Outside CT and MR images of 136 patients with known or presumed head and neck cancer were reinterpreted by a neuroradiologist. Clinical history and findings on physical examination were available. Reinterpretation was performed before review of outside reports, which were subsequently compared with those generated at the cancer center. Changes in interpretation were noted, and their effects on TNM staging, patient care, and prognosis were assessed. Reliability and statistical significance of rates of change in diagnosis were analyzed with 95% confidence intervals (CIs) and the sign test, respectively. Verification of change in diagnosis was confirmed by pathologic analysis (75%), characteristic radiologic findings (18%), or clinical and imaging follow-up (7%).RESULTS: Change in interpretation occurred in 56 patients (41%) (95% CI: 33–49%, P < .001). Forty-six patients (34%) had a change in T, N, and/or M staging (26–42%, P < .001). Change in T stage occurred in 27 cases (20%) (13–27%, P < .001) (upstaged in 22, downstaged in five), and a change in N stage in 26 cases (19%) (12–26%, P < .001) (upstaged in 20, downstaged in six). Two patients (1.5%) had missed systemic metastases. Three patients with an initial diagnosis of cancer were found to be cancer-free, and six patients had a diagnosis of new second primary cancers that were missed at original interpretation. One patient had a missed middle cerebral artery aneurysm. Changes in image interpretation altered treatment in 55 (98%) of 56 patients and affected prognosis in 53 patients (95%) (P < .001).CONCLUSION: Reinterpretation of cross-sectional images in the setting of a multidisciplinary cancer center has a significant effect on staging, management, and prognosis in patients with head and neck cancer. ER -