RT Journal Article
SR Electronic
T1 Does Streaming Affect the Cerebral Distribution of Infraophthalmic Intracarotid Chemotherapy?
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1732
OP 1735
VO 23
IS 10
A1 Ronit Agid
A1 Rina Rubinstein
A1 Tali Siegal
A1 Hava Lester
A1 Felix Bokstein
A1 Roland Chisin
A1 John M. Gomori
YR 2002
UL http://www.ajnr.org/content/23/10/1732.abstract
AB BACKGROUND AND PURPOSE: The development of new non–ocular-toxic drugs has enabled infraophthalmic chemotherapeutic infusion. We assessed whether streaming occurs with infraophthalmic, high cervical internal carotid artery (ICA) delivery of chemotherapeutic agents by means of conventional angiographic catheters.METHODS: Six patients with high-grade gliomas treated with monthly carotid intraarterial chemotherapy were studied. Chemotherapy delivery and distribution was modeled by technetium 99m hexylmethyl-propyleneamine oxine (HMPAO), a first-pass agent. Each patient received 0.5 mCi (18.5 MBq) of 99mTc-HMPAO in 50-mL of saline intraarterially in the ICA at the C1–C2 level. Injections were given twice, at two different injection rates: 0.08 mL/s at one therapeutic session and 6 mL/s a month later. The slow injection rate modeled the slowest rate used in the delivery of chemotherapy into the ICA. The higher rate was selected to avoid any possibility of uneven mixing, by replacing intracarotid blood completely and by using a turbulent injection rate that destroys laminar flow and intraarterial streaming. Single photon emission CT (SPECT) was performed 2 hours after injection. For each patient, the corresponding SPECT sections at the two injection rates were compared.RESULTS:No differences were noted in 99mTc-HMPAO distribution between the two injection rates in any of the patients. However, some of the rapid injection rate SPECT scans showed extension of the 99mTc-HMPAO uptake into adjacent watershed territories.CONCLUSION: There was no evidence, in humans, of substantial streaming during slow infraophthalmic intracarotid injections. Slow rates of infusion are as good as high rates for infraophthalmic intracarotid drug delivery. This is of special importance for drugs that are not tolerated at high injection rates. Moreover, infraophthalmic intracarotid chemotherapeutic infusion does not require special injectors or catheters.