RT Journal Article
SR Electronic
T1 Reproducibility of Proton MR Spectroscopic Imaging (PEPSI): Comparison of Dyslexic and Normal-Reading Children and Effects of Treatment on Brain Lactate Levels during Language Tasks
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1678
OP 1685
VO 23
IS 10
A1 Todd L. Richards
A1 Virginia W. Berninger
A1 Elizabeth H. Aylward
A1 Anne L. Richards
A1 Jennifer B. Thomson
A1 William E. Nagy
A1 Joanne F. Carlisle
A1 Stephen R. Dager
A1 Robert D. Abbott
YR 2002
UL http://www.ajnr.org/content/23/10/1678.abstract
AB BACKGROUND AND PURPOSE: We repeated a proton echo-planar spectroscopic imaging (PEPSI) study to test the hypothesis that children with dyslexia and good readers differ in brain lactate activation during a phonologic judgment task before but not after instructional treatment.METHODS: We measured PEPSI brain lactate activation (TR/TE, 4000/144; 1.5 T) at two points 1–2 months apart during two language tasks (phonologic and lexical) and a control task (passive listening). Dyslexic participants (n = 10) and control participants (n = 8) (boys and girls aged 9–12 years) were matched in age, verbal intelligence quotients, and valid PEPSI voxels. In contrast to patients in past studies who received combined treatment, our patients were randomly assigned to either phonologic or morphologic (meaning-based) intervention between the scanning sessions.RESULTS: Before treatment, the patients showed significantly greater lactate elevation in the left frontal regions (including the inferior frontal gyrus) during the phonologic task. Both patients and control subjects differed significantly in the right parietal and occipital regions during both tasks. After treatment, the two groups did not significantly differ in any brain region during either task, but individuals given morphologic treatment were significantly more likely to have reduced left frontal lactate activation during the phonologic task.CONCLUSION: The previous finding of greater left frontal lactate elevation in children with dyslexia during a phonologic judgment task was replicated, and brain activation changed as a result of treatment. However, the treatment effect was due to the morphologic component rather than the phonologic component.