TY - JOUR T1 - Disappearing Calvarium in Gorham Disease: MR Imaging Characteristics with Pathologic Correlation JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 415 LP - 418 VL - 25 IS - 3 AU - Chung-Ping Lo AU - Cheng-Yu Chen AU - Shy-Chyi Chin AU - Chun-Jung Juan AU - Chun-Jen Hsueh AU - Ann Chen Y1 - 2004/03/01 UR - http://www.ajnr.org/content/25/3/415.abstract N2 - Summary: Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced T1-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion. ER -