TY - JOUR T1 - Reversible MR Changes in the Cat Brain after Cerebral Fat Embolism Induced by Triolein Emulsion JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 958 LP - 963 VL - 25 IS - 6 AU - Chang H. Lee AU - Hak J. Kim AU - Hae G. Kim AU - Sang D. Lee AU - Suk M. Son AU - Yong W. Kim AU - Seung M. Kim AU - Choong K. Eun Y1 - 2004/06/01 UR - http://www.ajnr.org/content/25/6/958.abstract N2 - BACKGROUND AND PURPOSE: Clinical cerebral-fat embolism shows both reversible and irreversible changes. We used MR imaging to investigate the reversibility of embolized lesions induced with a fat-emulsion technique and to evaluate the histologic findings.METHODS: A fat emulsion was made with 0.05 mL of triolein and 20 mL of normal saline and vigorous to-and-fro movement through a three-way stopcock. In 50 cats, the internal carotid artery was infused with the fat emulsion. Cats were divided into six groups on the basis of time delay after embolization: 1 hour; 1 and 4 days; and 1, 2, and 3 weeks. MR imaging and histologic examination were performed at these times.RESULTS: Embolized lesions were hyperintense on T2-weighted images, isointense or mildly hyperintense on diffusion-weighted images, isointense on apparent diffusion coefficient maps, and enhancing on gadolinium-enhanced T1-weighted images at 1 hour. These MR imaging findings were less evident at day 1 and reverted to normal after day 4 (isointense on all images). Electron microscopy showed minimal findings in the cortical lesion in groups 1 and 2 (group 1 at 1 hour and group 2 at 1 hour and 1 day). Light microscopic findings revealed evidence of necrosis—small focal gliosis and demyelination in the periventricular white matter—in only one cat. The number of intravascular fat globules was not significantly different between groups, as visualized by oil red O staining.CONCLUSION: Cerebral-fat embolism induced by a triolein emulsion revealed reversible MR findings and minimal histologic findings. ER -