PT  - JOURNAL ARTICLE
AU  - Efrat Saraf-Lavi
AU  - Brian C. Bowen
AU  - Pradip M. Pattany
AU  - Evelyn M.L. Sklar
AU  - James B. Murdoch
AU  - Carol K. Petito
TI  - Proton MR Spectroscopy of Gliomatosis Cerebri: Case Report of Elevated Myoinositol with Normal Choline Levels
DP  - 2003 May 01
TA  - American Journal of Neuroradiology
PG  - 946--951
VI  - 24
IP  - 5
4099  - http://www.ajnr.org/content/24/5/946.short
4100  - http://www.ajnr.org/content/24/5/946.full
SO  - Am. J. Neuroradiol.2003 May 01; 24
AB  - Summary: A 69-year-old woman presented with clinical and imaging findings suspicious for gliomatosis cerebri, later confirmed by biopsy (moderately cellular, infiltrating glioma). Single voxel proton MR spectroscopy (TE 20 and TE 135) and spectroscopic imaging (TE 135) performed at admission showed normal choline, decreased N-acetyl, and elevated myo-inositol levels relative to creatine. The primary conclusion is that in suspected cases of gliomatosis cerebri, myo-inositol/creatine and myo-inositol/N-acetyl should be determined because they may provide evidence of tumor, even though choline/creatine is normal. A corollary to this conclusion is that choline/creatine may be misleading if used to demarcate infiltrating glioma from edema.