TY - JOUR T1 - Reversible White Matter Lesion in Methionine Adenosyltransferase I/III Deficiency JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1843 LP - 1845 VL - 25 IS - 10 AU - Hiroko Tada AU - Jun-ichi Takanashi AU - A. James Barkovich AU - Shigenori Yamamoto AU - Yoichi Kohno Y1 - 2004/11/01 UR - http://www.ajnr.org/content/25/10/1843.abstract N2 - Summary: A 5-year-old boy with methionine adenosyltransferase (MAT) I/III deficiency, under treatment for the tentative diagnosis of homocystinuria, presented with mildly decreased appetite and sleepiness. MR imaging showed abnormal T1 and T2 prolongations and reduced diffusion in the cerebral white matter. Clinical symptoms and MR imaging findings improved after discontinuation of therapy. We speculate that inappropriate treatment might enhance CNS lesions of MAT I/III deficiency by causing a reversible vacuolating myelinopathy. ER -