TY - JOUR T1 - Malformation of Cortical and Vascular Development in One Family with Parietal Foramina Determined by an <em>ALX4</em> Homeobox Gene Mutation JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1836 LP - 1839 VL - 25 IS - 10 AU - Marcelo Valente AU - Kette D. Valente AU - Sofia S. M. Sugayama AU - Chong Ae Kim Y1 - 2004/11/01 UR - http://www.ajnr.org/content/25/10/1836.abstract N2 - Summary: Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2), which is determined by the ALX4 gene. It is believed that ALX4 has a bone-restricted expression. We report a case of PFM with age-related size variation in a 4-year-old boy, as well as in his mother, aunt and grandfather. MR imaging of the child demonstrates prominent malformations of cortical (polymicrogyric cortex with an unusual infolding pattern) and vascular development (persistence median prosencephalic vein), associated with high tentorial incisure periatrial white matter changes. ER -