RT Journal Article
SR Electronic
T1 Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1887
OP 1890
VO 24
IS 9
A1 Sandoval, Claudio
A1 Kutscher, Martin
A1 Jayabose, Somasundaram
A1 Tenner, Michael
YR 2003
UL http://www.ajnr.org/content/24/9/1887.abstract
AB Summary: We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.