RT Journal Article
SR Electronic
T1 Quantitative MR Diffusion Mapping and Cyclosporine-Induced Neurotoxicity
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1507
OP 1510
VO 20
IS 8
A1 Coley, Stuart C.
A1 Porter, David A.
A1 Calamante, Fernando
A1 Chong, Wui K.
A1 Connelly, Alan
YR 1999
UL http://www.ajnr.org/content/20/8/1507.abstract
AB Summary: Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.