TY - JOUR T1 - The Value of Apparent Diffusion Coefficient Maps in Early Cerebral Ischemia JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1260 LP - 1267 VL - 22 IS - 7 AU - Patricia M. Desmond AU - Amanda C. Lovell AU - Andrew A. Rawlinson AU - Mark W. Parsons AU - P. Alan Barber AU - Qing Yang AU - Ting Li AU - David G. Darby AU - Richard P. Gerraty AU - Steven M. Davis AU - Brian M. Tress Y1 - 2001/08/01 UR - http://www.ajnr.org/content/22/7/1260.abstract N2 - BACKGROUND AND PURPOSE: Prediction of the regions of the ischemic penumbra that are likely to progress to infarction is of great clinical interest. Whether lowered apparent diffusion coefficient (ADC) values were present in the ischemic penumbra of patients presenting with acute ischemic stroke and were specific to regions of the penumbra that proceeded to infarction was investigated.METHODS: Nineteen patients with hemispheric stroke of less than 6 hours' onset and with acute scans showing a perfusion lesion greater than a diffusion lesion (ischemic penumbra) were studied. Scans also were performed subacutely (days 3 to 5) and at outcome (day 90). The outcome scan was used to identify regions of the penumbra that proceeded to infarction.RESULTS: The ADC ratios were significantly reduced (P < .00001) in regions of the penumbra that progressed to infarction on the outcome scan compared with those that remained normal. In regions that showed transition to infarction, the mean ADC ratios were typically 0.75 to 0.90.CONCLUSION: Intermediate ADC values are present in the ischemic penumbra and are indicative of tissue at risk of infarction. ER -