PT  - JOURNAL ARTICLE
AU  - Janneke Schuuring
AU  - Pieter Wesseling
AU  - Aad Verrips
TI  - Severe Tacrolimus Leukoencephalopathy after Liver Transplantation
DP  - 2003 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2085--2088
VI  - 24
IP  - 10
4099  - http://www.ajnr.org/content/24/10/2085.short
4100  - http://www.ajnr.org/content/24/10/2085.full
SO  - Am. J. Neuroradiol.2003 Nov 01; 24
AB  - Summary: Tacrolimus is an immunosuppressive agent that can show a wide variety of neurologic side effects, including leukoencephalopathy. Although the prognosis is good—after cessation or dose reduction, complete recovery usually occurs—the differentiation with treatable diseases such as progressive multifocal encephalopathy can be difficult, making a stereotactic biopsy of the white matter lesion sometimes necessary. We describe the case of a 12-year-old girl with a severe, reversible tacrolimus-related leukoencephalopathy and only mild histopathologic abnormalities.