RT Journal Article
SR Electronic
T1 Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP E134
OP E138
DO 10.3174/ajnr.A2152
VO 32
IS 7
A1 T. Schneider
A1 J. Hom
A1 J. Bredno
A1 J.W. Dankbaar
A1 S.-C. Cheng
A1 M. Wintermark
YR 2011
UL http://www.ajnr.org/content/32/7/E134.abstract
AB SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT. ACAanterior cerebral arteryAIFarterial input functionBBBblood-brain barrierBBBPblood-brain barrier permeabilityCBFcerebral blood flowCBVcerebral blood volumeCIconfidence intervalCTACT angiographyFLAIRfluid-attenuated inversion recoveryGEEgeneralized estimating equationsMCAmiddle cerebral artery√MSEroot mean squared errorsMSEmean squared errorMTTmean transit timeNCCTnoncontrast CTPCAposterior cerebral arteryPCTperfusion CTPETpositron-emission tomographyRIFregion input functionrtPArecombinant tissue plasminogen activatorTTPtime to peak