TY - JOUR T1 - Cortical Laminar Necrosis Caused by Immunosuppressive Therapy and Chemotherapy JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 479 LP - 484 VL - 21 IS - 3 AU - Nuria Bargalló AU - Marta Burrel AU - Joan Berenguer AU - Federico Cofan AU - Laura Buñesch AU - Josep M. Mercader Y1 - 2000/03/01 UR - http://www.ajnr.org/content/21/3/479.abstract N2 - Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyperintense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients. ER -