PT  - JOURNAL ARTICLE
AU  - Aristides A. Capizzano
AU  - Norbert Schuff
AU  - Diane L. Amend
AU  - Jody L. Tanabe
AU  - David Norman
AU  - Andrew A. Maudsley
AU  - William Jagust
AU  - Helena C. Chui
AU  - George Fein
AU  - Mark R. Segal
AU  - Michael W. Weiner
TI  - Subcortical Ischemic Vascular Dementia: Assessment with Quantitative MR Imaging and <sup>1</sup>H MR Spectroscopy
DP  - 2000 Apr 01
TA  - American Journal of Neuroradiology
PG  - 621--630
VI  - 21
IP  - 4
4099  - http://www.ajnr.org/content/21/4/621.short
4100  - http://www.ajnr.org/content/21/4/621.full
SO  - Am. J. Neuroradiol.2000 Apr 01; 21
AB  - BACKGROUND AND PURPOSE: Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography. The aim of this study was to characterize, by means of MR imaging and 1H MR spectroscopy, the structural and metabolic brain changes that occur among patients with subcortical ischemic vascular dementia compared with those of elderly control volunteers and patients with Alzheimer's disease.METHODS: Patients with dementia and lacunes (n = 11), cognitive impairment and lacunes (n = 14), and dementia without lacunes (n = 18) and healthy age-matched control volunteers (n = 20) underwent MR imaging and 1H MR spectroscopy. 1H MR spectroscopy data were coanalyzed with coregistered segmented MR images to account for atrophy and tissue composition.RESULTS: Compared with healthy control volunteers, patients with dementia and lacunes had 11.74% lower N-acetylaspartate/creatine ratios (NAA/Cr) (P = .007) and 10.25% lower N-acetylaspartate measurements (NAA) in the cerebral cortex (P = .03). In white matter, patients with dementia and lacunes showed a 10.56% NAA/Cr reduction (P = .01) and a 12.64% NAA reduction (P = .04) compared with control subjects. NAA in the frontal cortex was negatively correlated with the volume of white matter signal hyperintensity among patients with cognitive impairment and lacunes (P = .002). Patients with dementia, but not patients with dementia and lacunes, showed a 10.33% NAA/Cr decrease (P = .02) in the hippocampus compared with healthy control volunteers.CONCLUSION: Patients with dementia and lacunes have reduced NAA and NAA/Cr in both cortical and white matter regions. Cortical changes may result from cortical ischemia/infarction, retrograde or trans-synaptic injury (or both) secondary to subcortical neuronal loss, or concurrent Alzheimer's pathologic abnormalities. Cortical derangement may contribute to dementia among patients with subcortical infarction.