TY - JOUR T1 - Biologic Imaging of Head and Neck Cancer: The Present and the Future JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 586 LP - 594 DO - 10.3174/ajnr.A2535 VL - 33 IS - 4 AU - A. Srinivasan AU - S. Mohan AU - S.K. Mukherji Y1 - 2012/04/01 UR - http://www.ajnr.org/content/33/4/586.abstract N2 - SUMMARY: While anatomic imaging (CT and MR imaging) of HNC is focused on diagnosing and/or characterizing the disease, defining its local extent, and evaluating distant spread, accurate assessment of the biologic status of the cancer (cellularity, growth rate, response to nonsurgical chemoradiation therapy, and so forth) can be invaluable for prognostication, planning therapy, and follow-up of lesions after therapy. The combination of anatomic and biologic imaging techniques can thus provide a more comprehensive evaluation of the patient. The purpose of this work was to review the present and future clinical applications of advanced biologic imaging techniques in HNC evaluation and management. As part of the biologic imaging array, we discuss MR spectroscopy, diffusion and perfusion MR imaging, CTP, and FDG-PET scanning and conclude with exciting developments that hold promise in assessment of tumor hypoxia and neoangiogenesis. ADCapparent diffusion coefficientBFblood flowBVblood volumeChocholineCrcreatineCPcapillary permeabilityCTPCT perfusionDCEdynamic contrast-enhancedDTIdiffusion tensor imagingDWIdiffusion-weighted MR imaging18Ffluorine 18FMISOfluoromisonidazoleFDG-PETfluorodeoxyglucose–positron-emission tomographyFLTfluorothymidineGTVgross tumor volumeHNChead and neck cancerKtransaverage contrast transfer coefficientMTTmean transit timeMVDmean vessel attenuationPETpositron-emission tomographyPRMparametric response mapRGDarginine-glycine-aspartic acid ER -