%0 Journal Article %A W.-W. Lee %A J.-S. Kim %A K.R. Son %A H.-M. Kwon %T Atypical Diffusion-Restricted Lesion in 5-Fluorouracil Encephalopathy %D 2012 %R 10.3174/ajnr.A2781 %J American Journal of Neuroradiology %P E102-E103 %V 33 %N 7 %X SUMMARY: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging. BUNblood urea nitrogenCRFchronic renal failureDPDdihydropyrimidine dehydrogenase5-FU5-fluorouracilPT/INRprothrombin time/international normalized ratio %U https://www.ajnr.org/content/ajnr/33/7/E102.full.pdf