%0 Journal Article %A H. Kato %A E. Shimosegawa %A K. Isohashi %A N. Kimura %A H. Kazui %A J. Hatazawa %T Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction %D 2012 %R 10.3174/ajnr.A3005 %J American Journal of Neuroradiology %P 1458-1463 %V 33 %N 8 %X BACKGROUND AND PURPOSE: CBR imaging is highly susceptible to a PVE produced by morphologic changes in the brain related to aging and brain laterality. We assessed the influence of PVE produced by regional age-related changes in gray matter volume on I-123 iomazenil SPECT and elucidated the age-related changes in human CBR binding by using PVE-corrected SPECT images. MATERIALS AND METHODS: Nineteen right-handed healthy volunteers (range, 25–82 years; mean, 55 ± 21 years) underwent MR imaging and quantitative I-123 iomazenil SPECT imaging. The influence of age-related changes in rGMC on SPECT images before PVE correction was assessed. PVE correction of the SPECT images was performed by using an MR imaging–based method. Voxel-based linear regression analyses of the PVE-corrected SPECT images were performed by using SPM5. RESULTS: The age-related reductions in rGMC and BP without PVE correction revealed a significant direct proportional correlation. Voxel-based statistical analysis with PVE correction showed no significant age-related changes in BP. CONCLUSIONS: PVE correction was indispensable for the analysis of I-123 iomazenil SPECT images. PVE-corrected quantitative I-123 iomazenil SPECT images revealed no age-related changes in CBR binding in right-handed healthy humans. AALautomated anatomic labelingBPbinding potentialCBRcentral benzodiazepine receptorFWHMfull width at half maximumI-123iodine 123PSFpoint-spreading functionPVEpartial volume effectrGMCregional gray matter concentrationSPMstatistical parametric mappingVBMvoxel-based morphometry %U https://www.ajnr.org/content/ajnr/33/8/1458.full.pdf