RT Journal Article
SR Electronic
T1 Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1458
OP 1463
DO 10.3174/ajnr.A3005
VO 33
IS 8
A1 H. Kato
A1 E. Shimosegawa
A1 K. Isohashi
A1 N. Kimura
A1 H. Kazui
A1 J. Hatazawa
YR 2012
UL http://www.ajnr.org/content/33/8/1458.abstract
AB BACKGROUND AND PURPOSE: CBR imaging is highly susceptible to a PVE produced by morphologic changes in the brain related to aging and brain laterality. We assessed the influence of PVE produced by regional age-related changes in gray matter volume on I-123 iomazenil SPECT and elucidated the age-related changes in human CBR binding by using PVE-corrected SPECT images. MATERIALS AND METHODS: Nineteen right-handed healthy volunteers (range, 25–82 years; mean, 55 ± 21 years) underwent MR imaging and quantitative I-123 iomazenil SPECT imaging. The influence of age-related changes in rGMC on SPECT images before PVE correction was assessed. PVE correction of the SPECT images was performed by using an MR imaging–based method. Voxel-based linear regression analyses of the PVE-corrected SPECT images were performed by using SPM5. RESULTS: The age-related reductions in rGMC and BP without PVE correction revealed a significant direct proportional correlation. Voxel-based statistical analysis with PVE correction showed no significant age-related changes in BP. CONCLUSIONS: PVE correction was indispensable for the analysis of I-123 iomazenil SPECT images. PVE-corrected quantitative I-123 iomazenil SPECT images revealed no age-related changes in CBR binding in right-handed healthy humans. AALautomated anatomic labelingBPbinding potentialCBRcentral benzodiazepine receptorFWHMfull width at half maximumI-123iodine 123PSFpoint-spreading functionPVEpartial volume effectrGMCregional gray matter concentrationSPMstatistical parametric mappingVBMvoxel-based morphometry