RT Journal Article
SR Electronic
T1 MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1525
OP 1529
DO 10.3174/ajnr.A2987
VO 33
IS 8
A1 G.Q. Hou
A1 J.C. Sun
A1 X.J. Zhang
A1 B.X. Shen
A1 X.J. Zhu
A1 L. Liang
A1 X.L. Zhang
YR 2012
UL http://www.ajnr.org/content/33/8/1525.abstract
AB SUMMARY: Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations. EMAepithelial membrane antigenHMB-45human melanoma black-45IHCimmunohistochemistryMMmeningeal melanocytoma