TY - JOUR T1 - Comparison of Phase-Contrast MR Imaging and Endovascular Sonography for Intracranial Blood Flow Velocity Measurements JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1786 LP - 1790 DO - 10.3174/ajnr.A3142 VL - 33 IS - 9 AU - J.J. Schneiders AU - S.P. Ferns AU - P. van Ooij AU - M. Siebes AU - A.J. Nederveen AU - R. van den Berg AU - J. van Lieshout AU - G. Jansen AU - E. vanBavel AU - C.B. Majoie Y1 - 2012/10/01 UR - http://www.ajnr.org/content/33/9/1786.abstract N2 - BACKGROUND AND PURPOSE: Local hemodynamic information may help to stratify rupture risk of cerebral aneurysms. Patient-specific modeling of cerebral hemodynamics requires accurate data on BFV in perianeurysmal arteries as boundary conditions for CFD. The aim was to compare the BFV measured with PC-MR imaging with that obtained by using intra-arterial Doppler sonography and to determine interpatient variation in intracranial BFV. MATERIALS AND METHODS: In 10 patients with unruptured intracranial aneurysms, BFV was measured in the cavernous ICA with PC-MR imaging in conscious patients before treatment, and measured by using an intra-arterial Doppler sonography wire when the patient was anesthetized with either propofol (6 patients) or sevoflurane (4 patients). RESULTS: Both techniques identified a pulsatile blood flow pattern in cerebral arteries. PSV differed >50 cm/s between patients. A mean velocity of 41.3 cm/s (95% CI, 39.3–43.3) was measured with PC-MR imaging. With intra-arterial Doppler sonography, a mean velocity of 29.3 cm/s (95% CI, 25.8–32.8) was measured with the patient under propofol-based intravenous anesthesia. In patients under sevoflurane-based inhaled anesthesia, a mean velocity of 44.9 cm/s (95% CI, 40.6–49.3) was measured. CONCLUSIONS: We showed large differences in BFV between patients, emphasizing the importance of using patient-specific hemodynamic boundary conditions in CFD. PC-MR imaging measurements of BFV in conscious patients were comparable with those obtained with the intra-arterial Doppler sonography when the patient was anesthetized with a sevoflurane-based inhaled anesthetic. BFVblood flow velocityCFDcomputational fluid dynamicsCIconfidence intervalPC-MRIphase contrast MR imagingPaCO2arterial CO2 pressurePSVpeak systolic velocityTCDtranscranial Doppler ER -