RT Journal Article
SR Electronic
T1 Monitoring Peri-Therapeutic Cerebral Circulation Time: A Feasibility Study Using Color-Coded Quantitative DSA in Patients with Steno-Occlusive Arterial Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1685
OP 1690
DO 10.3174/ajnr.A3049
VO 33
IS 9
A1 C.J. Lin
A1 S.C. Hung
A1 W.Y. Guo
A1 F.C. Chang
A1 C.B. Luo
A1 J. Beilner
A1 M. Kowarschik
A1 W.F. Chu
A1 C.Y. Chang
YR 2012
UL http://www.ajnr.org/content/33/9/1685.abstract
AB BACKGROUND AND PURPOSE: Intracranial hemodynamics are important for management of SOAD. This study aimed to monitor peri-stent placement intracranial CirT of patients with SOAD. MATERIALS AND METHODS: Twenty-five patients received stent placement for extracranial ICA stenosis, and 34 patients with normal CirT were recruited as controls. Their color-coded DSAs were used to define the Tmax of selected intravascular ROI. A total of 20 ROIs of the ICA, OphA, ACA, MCA, FV, PV, OV, SSS, SS, IJV, and MCV were selected. rTmax was defined as the Tmax at the selected region of interest minus Tmax at the cervical segment of the ICA (I1 on AP view and IA on lateral view). rTmax of the PV was defined as intracranial CirT. Intergroup and intragroup longitudinal comparisons of rTmax were performed. RESULTS: rTmax values of the normal cohorts were as follows: ICA-AP, 0.12; ICA-LAT, 0.10; A1, 0.28; A2, 0.53; A3, 0.81; M1, 0.40; M2, 0.80; M3, 0.95; OphA, 0.35; FV, 4.83; PV, 5.11; OV, 5.17; SSS, 6.16; SS, 6.51; IJV, 6.81; and MCV, 3.86 seconds. Before stent placement, the rTmax values of arterial ROIs, except A3 and M3, were prolonged compared with values from control subjects (P < .05). None of the rTmax of any venous ROIs in the stenotic group was prolonged with significance. After stent placement, the rTmax of all arterial ROIs shortened significantly, except A1and M3. Poststenting rTmax was not different from the control group. CONCLUSIONS: Without extra contrast medium and radiation dosages, color-coded quantitative DSA enables real-time monitoring of peri-therapeutic intracranial CirT in patients with SOAD . APanterior-posterior viewAUCarea under the ROC curveCIconfidence intervalCirTcirculation timeFVcortical veins at the frontal regionICA-APinternal carotid artery on anterior-posterior viewICA-LATinternal carotid artery on lateral viewICCintraclass correlation coefficientIJVinternal jugular veinMCVmiddle cerebral veinOphAophthalmic arteryOVcortical veins at occipital regionPVcortical veins at parietal regionrTmaxrelative TmaxROCreceiver operating characteristicSOADsteno-occlusive arterial diseaseSSsigmoid sinusSSSsuperior sagittal sinusTmaxtime to maximum opacification