RT Journal Article
SR Electronic
T1 Biometry of the Corpus Callosum in Children: MR Imaging Reference Data
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1436
OP 1443
DO 10.3174/ajnr.A2542
VO 32
IS 8
A1 C. Garel
A1 I. Cont
A1 C. Alberti
A1 E. Josserand
A1 M.L. Moutard
A1 H. Ducou le Pointe
YR 2011
UL http://www.ajnr.org/content/32/8/1436.abstract
AB BACKGROUND AND PURPOSE: The availability of data relating to the biometry of the CC in children that are easy to use in daily practice is limited. We present a reference biometry of the CC in MR imaging in a large cohort of children. MATERIALS AND METHODS: Cerebral MR imaging studies of children with normal examination findings were selected retrospectively. Children born preterm and those with or at risk of developing cerebral malformations were excluded. The following parameters were measured: FOD, APD, LCC, GT, BT, IT, ST, and the S/T. Inter- and intraobserver agreement and sex effect were evaluated. RESULTS: Six hundred twenty-two children were included (320 boys, 302 girls), ranging from 1 day to 15 years of age. Normal values (from the 3rd to 97th percentile) are provided for each parameter. All parameters showed rapid growth up to 3 years of age followed by slower (FOD, APD, LCC, GT and ST) or absent (S/T) growth. Growth of BT and IT was completed by 7–8 years. CC modeling (IT/ST) was completed by 3 years. FOD was larger in boys from the age of 1 year (statistically significant). The other parameters did not show any sex effect. Inter- and intraobserver agreement was excellent for all parameters except for IT. CONCLUSIONS: As measured, our data result in easy and reproducible MR imaging biometry of the CC in children. APDanteroposterior diameter of the corpus callosumBTbody thicknessCCcorpus callosumCIconfidence intervalENexponential normalFODfronto-occipital diameterGTgenu thicknessICCintra-class correlation coefficientITisthmus thicknessLOAlimits of agreementLCClength of the corpus callosumSTsplenium thicknessS/Tposition of the splenium related to the tegmentum