TY - JOUR T1 - MR Imaging of IgG4-Related Disease in the Head and Neck and Brain JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 2136 LP - 2139 DO - 10.3174/ajnr.A3147 VL - 33 IS - 11 AU - K. Toyoda AU - H. Oba AU - K. Kutomi AU - S. Furui AU - A. Oohara AU - H. Mori AU - K. Sakurai AU - K. Tsuchiya AU - S. Kan AU - Y. Numaguchi Y1 - 2012/12/01 UR - http://www.ajnr.org/content/33/11/2136.abstract N2 - SUMMARY: IgG4-related disease is characterized by histologic fibrosis with IgG4-positive plasma cell infiltration. Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4. AIPautoimmune pancreatitisHNhead and neckIgG4immunoglobulin G4IgG4-RDIgG4-related diseaseIPTinflammatory pseudotumorMDMikulicz diseaseSSSjögren syndromeV1first division of the trigeminal nerve (CN V)V2second division of the trigeminal nerve ER -