RT Journal Article
SR Electronic
T1 The Effect of Paramagnetic Contrast in Choline Peak in Patients with Glioblastoma Multiforme Might Not Be Significant
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 80
OP 84
DO 10.3174/ajnr.A3181
VO 34
IS 1
A1 E.C. Lima
A1 M.C.G. Otaduy
A1 M. Tsunemi
A1 R. Pincerato
A1 E.F. Cardoso
A1 S. Rosemberg
A1 P.H. Aguiar
A1 G.G. Cerri
A1 C.C. Leite
YR 2013
UL http://www.ajnr.org/content/34/1/80.abstract
AB BACKGROUND AND PURPOSE: 1H-MR spectroscopy is a useful tool in brain tumor evaluation. A critical point in obtaining representative spectra is the correct voxel positioning, which can be more accurate after Gd administration. Some experimental data suggested that Gd could cause Cho signal loss. Our aim was to evaluate the effect of Gd in the Cho peak area and width in patients with GBM. MATERIALS AND METHODS: We performed multivoxel 1H-MR spectroscopy before and after Gd administration in 18 patients with GBM. Quantification of Cho peak area and width in each voxel was completed, and the Cho mean and maximum values before and after Gd injection were calculated in the tumor and contralateral hemisphere. Choline peak area and width values obtained before and after contrast were compared, considering as separate entities enhancing and nonenhancing tumoral voxels and the contralateral hemisphere. RESULTS: No statistically significant differences were found for the Cho peak area mean values in the tumoral voxels or contralaterally (P > .05). A tendency for an increase in the Cho peak width mean value was found in the tumoral enhancing voxels (P = .055). A statistically significant decrease was found for the mean value of the maximum Cho peak area in enhancing tumoral voxels (P = .020). No significant differences were found in the nonenhancing tumoral voxels or contralaterally (P > .05). CONCLUSIONS: The injection of Gd before performing 1H-MR spectroscopy might not significantly affect the Cho peak area in patients with GBM. The paramagnetic contrast seems to cause a different effect, depending on Gd enhancement. GdgadoliniumGD-DTPAgadopentetate dimeglumineGD-DTPA-BMAgadodiamideGBMglioblastoma multiformeGD-DOTAgadoterate meglumine