RT Journal Article
SR Electronic
T1 Robust Perfusion Deficits in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 62
OP 67
DO 10.3174/ajnr.A3148
VO 34
IS 1
A1 P.L. Francis
A1 R. Jakubovic
A1 P. O'Connor
A1 L. Zhang
A1 A. Eilaghi
A1 L. Lee
A1 T.J. Carroll
A1 J. Mouannes-Srour
A1 A. Feinstein
A1 R.I. Aviv
YR 2013
UL http://www.ajnr.org/content/34/1/62.abstract
AB BACKGROUND AND PURPOSE: Cognitive impairment is a common, disabling symptom of MS. We investigated the impact of cerebral perfusion and brain and lesion volumetry on cognitive performance in 45 patients with SPMS by using MR imaging. MATERIALS AND METHODS: Cognition was assessed by using a standard battery, the Minimal Assessment of Cognitive Function in Multiple Sclerosis. qCBF and qCBV maps were analyzed by using SPM and PLS. SPM was also used to conduct the GM, WM, and WML volumetric analyses. RESULTS: Both SPM and PLS demonstrated significantly reduced qCBV in the superior medial frontal cortex of impaired patients. PLS also revealed significantly lower qCBV in the bilateral thalami and caudate nuclei of impaired patients and identified a pattern of significantly attenuated qCBF similar to that of qCBV. Performance on the Symbol Digit Modalities Test, which assesses information-processing speed, correlated most strongly overall with cerebral perfusion. Focal (ie, voxelwise) analyses of GM, WM, and WML volume revealed no significant differences between patients with and without cognitive impairment, though global GM volume was significantly decreased and global WML volume was significantly increased in impaired patients. CONCLUSIONS: These results suggest that cognitively impaired patients with SPMS exhibit robust perfusion deficits in cortical and subcortical GM and impaired processing speed. BABrodmann areaDSCdynamic susceptibility contrastFWEfamily-wise errorGMgray matterkEextent thresholdLVlatent variableMNIMontreal Neurological InstitutePLSPartial Least SquaresqCBFquantitative CBFqCBVquantitative CBVSPMStatistical Parametric MappingSPMSsecondary–progressive MSWMLwhite matter lesion