RT Journal Article
SR Electronic
T1 Functional Homotopic Changes in Multiple Sclerosis with Resting-State Functional MR Imaging
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1180
OP 1187
DO 10.3174/ajnr.A3386
VO 34
IS 6
A1 Y. Zhou
A1 M. Milham
A1 X.-N. Zuo
A1 C. Kelly
A1 H. Jaggi
A1 J. Herbert
A1 R.I. Grossman
A1 Y. Ge
YR 2013
UL http://www.ajnr.org/content/34/6/1180.abstract
AB BACKGROUND AND PURPOSE: CC is extensively involved in MS with interhemispheric dysfunction. The purpose of this study was to determine whether interhemispheric correlation is altered in MS by use of a recently developed RS-fMRI homotopy technique and whether these homotopic changes correlate with CC pathology. MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting MS and 24 age-matched healthy volunteers were studied with RS-fMRI and DTI acquired at 3T. The Pearson correlation of each pair of symmetric interhemispheric voxels of RS-fMRI time-series data was performed to compute VMHC, and z-transformed for subsequent group-level analysis. In addition, 5 CC segments in the midsagittal area and DTI-derived FA were measured to quantify interhemispheric microstructural changes and correlate with global and regional VMHC in MS. RESULTS: Relative to control participants, patients with MS exhibited an abnormal homotopic pattern with decreased VMHC in the primary visual, somatosensory, and motor cortices and increased VMHC in several regions associated with sensory processing and motor control including the insula, thalamus, pallidum, and cerebellum. The global VMHC correlates moderately with the average FA of the entire CC for all participants in both groups (r = 0.3; P = .03). CONCLUSIONS: Our data provide preliminary evidence of the potential usefulness of VMHC analyses for the detection of abnormalities of interhemispheric coordination in MS. We demonstrated that the whole-brain homotopic RS-fMRI pattern was altered in patients with MS, which was partially associated with the underlying structural degenerative changes of CC measured with FA. CCcorpus callosumCSTcortical spinal tractFAfractional anisotropyRSFCresting-state functional connectivityRS-fMRIresting-state functional MRIVMHCvoxel-mirrored homotopic correlation