PT - JOURNAL ARTICLE AU - M. Mascalchi AU - A. Bianchi AU - M. Basile AU - P. Gulino AU - M.R. Trifan AU - D. Difeo AU - E. Bartolini AU - C. Defilippi AU - S. Diciotti TI - Effectiveness of 3D T2-Weighted FLAIR FSE Sequences with Fat Suppression for Detection of Brain MR Imaging Signal Changes in Children AID - 10.3174/ajnr.A4915 DP - 2016 Dec 01 TA - American Journal of Neuroradiology PG - 2376--2381 VI - 37 IP - 12 4099 - http://www.ajnr.org/content/37/12/2376.short 4100 - http://www.ajnr.org/content/37/12/2376.full SO - Am. J. Neuroradiol.2016 Dec 01; 37 AB - BACKGROUND AND PURPOSE: T2-weighted FLAIR can be combined with 3D-FSE sequences with isotropic voxels, yielding higher signal-to-noise ratio than 2D-FLAIR. Our aim was to explore whether a T2-weighted FLAIR–volume isotropic turbo spin-echo acquisition sequence (FLAIR-VISTA) with fat suppression shows areas of abnormal brain T2 hyperintensities with better conspicuity in children than a single 2D-FLAIR sequence.MATERIALS AND METHODS: One week after a joint training session with 20 3T MR imaging examinations (8 under sedation), 3 radiologists independently evaluated the presence and conspicuity of abnormal areas of T2 hyperintensities of the brain in FLAIR-VISTA with fat suppression (sagittal source and axial and coronal reformatted images) and in axial 2D-FLAIR without fat suppression in a test set of 100 3T MR imaging examinations (34 under sedation) of patients 2–18 years of age performed for several clinical indications. Their agreement was measured with weighted κ statistics.RESULTS: Agreement was “substantial” (mean, 0.61 for 3 observers; range, 0.49–0.69 for observer pairs) for the presence of abnormal T2 hyperintensities and “fair” (mean, 0.29; range, 0.23–0.38) for the comparative evaluation of lesion conspicuity. In 21 of 23 examinations in which the 3 radiologists agreed on the presence of abnormal T2 hyperintensities, FLAIR-VISTA with fat suppression images were judged to show hyperintensities with better conspicuity than 2D-FLAIR. In 2 cases, conspicuity was equal, and in no case was conspicuity better in 2D-FLAIR.CONCLUSIONS: FLAIR-VISTA with fat suppression can replace the 2D-FLAIR sequence in brain MR imaging protocols for children.VISTAvolume isotropic turbo spin-echo acquisition