RT Journal Article
SR Electronic
T1 Metabolite Differences in the Lenticular Nucleus in Type 2 Diabetes Mellitus Shown by Proton MR Spectroscopy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1692
OP 1696
DO 10.3174/ajnr.A3492
VO 34
IS 9
A1 Y. Lin
A1 J. Zhou
A1 L. Sha
A1 Y. Li
A1 X. Qu
A1 L. Liu
A1 H. Chen
A1 Z. An
A1 Y. Wang
A1 C. Sun
YR 2013
UL http://www.ajnr.org/content/34/9/1692.abstract
AB BACKGROUND AND PURPOSE: Previous studies by using proton MR spectroscopy found metabolite abnormalities in the cerebral cortex and white matter of patients with type 2 diabetes mellitus. The present study was undertaken to detect metabolite differences in the lenticular nuclei and thalamus in patients with T2DM. MATERIALS AND METHODS: Twenty subjects with T2DM and 22 age-matched control subjects underwent single-voxel MR spectroscopy in the left and right lenticular nuclei and left and right thalami. NAA/Cr and Cho/Cr ratios were calculated. Brain lactic acid, fasting blood glucose, and glycosylated hemoglobin levels were also monitored. RESULTS: The NAA/Cr ratio was lower in the left lenticular nuclei of subjects with T2DM (P = .007), whereas the Cho/Cr ratio was increased in both the and right lenticular nuclei (P = .001). The NAA/Cr ratio was negatively correlated with FBG in the left (r = −0.573, P = .008) and right nuclei (r = −0.564, P = .010). It was also negatively correlated to HbA1c in the left (r = −0.560, P = .010) and right (r = −0.453, P = .045) nuclei. The Cho/Cr ratio was positively correlated with these variables (P < .05). No significant differences in NAA/Cr or Cho/Cr ratios were observed in the thalamus of patients with T2DM. Lactic acid was not detected in any of the patients in the study. CONCLUSIONS: The different metabolic statuses of the lenticular nuclei and thalamus suggest different effects of T2DM in each of these brain nuclei, with the lenticular nuclei being more vulnerable than the thalamus. The abnormal metabolic status was observed before lesions had appeared in these brain areas. T2DMtype 2 diabetes mellitusDMdiabetes mellitusFBGfasting blood glucoseHbA1cglycosylated hemoglobin