%0 Journal Article %A J. Barakos %A R. Sperling %A S. Salloway %A C. Jack %A A. Gass %A J.B. Fiebach %A D. Tampieri %A D. Melançon %A Y. Miaux %A G. Rippon %A R. Black %A Y. Lu %A H.R. Brashear %A H.M. Arrighi %A K.A. Morris %A M. Grundman %T MR Imaging Features of Amyloid-Related Imaging Abnormalities %D 2013 %R 10.3174/ajnr.A3500 %J American Journal of Neuroradiology %P 1958-1965 %V 34 %N 10 %X BACKGROUND AND PURPOSE: AD is one of the few leading causes of death without a disease-modifying drug; however, hopeful agents are in various phases of development. MR imaging abnormalities, collectively referred to as amyloid-related imaging abnormalities, have been reported for several agents that target cerebral Aβ burden. ARIA includes ARIA-E, parenchymal or sulcal hyperintensities on FLAIR indicative of parenchymal edema or sulcal effusions, and ARIA-H, hypointense regions on gradient recalled-echo/T2* indicative of hemosiderin deposition. This report describes imaging characteristics of ARIA-E and ARIA-H identified during studies of bapineuzumab, a humanized monoclonal antibody against Aβ. MATERIALS AND METHODS: Two neuroradiologists with knowledge of imaging changes reflective of ARIA reviewed MR imaging scans from 210 bapineuzumab-treated patients derived from 3 phase 2 studies. Each central reader interpreted the studies independently, and discrepancies were resolved by consensus. The inter-reader κ was 0.76, with 94% agreement between neuroradiologists regarding the presence or absence of ARIA-E in individual patients. RESULTS: Thirty-six patients were identified with incident ARIA-E (17.1%, 36/210) and 26 with incident ARIA-H (12.4%, 26/210); of those with incident ARIA-H, 24 had incident microhemorrhages and 2 had incident large superficial hemosiderin deposits. CONCLUSIONS: In 49% of cases of ARIA-E, there was the associated appearance of ARIA-H. In treated patients without ARIA-E, the risk for incident blood products was 4%. This association between ARIA-E and ARIA-H may suggest a common pathophysiologic mechanism. Familiarity with ARIA should permit radiologists and clinicians to recognize and communicate ARIA findings more reliably for optimal patient management. Aβamyloid-βADAlzheimer diseaseARIAamyloid-related imaging abnormalitiesARIA-Eamyloid-related imaging abnormalities associated with edema or effusion/exudateARIA-Hamyloid-related imaging abnormalities associated with hemosiderin deposition %U https://www.ajnr.org/content/ajnr/34/10/1958.full.pdf