PT - JOURNAL ARTICLE AU - R. Zivadinov AU - N. Bergsland AU - O. Dolezal AU - S. Hussein AU - Z. Seidl AU - M.G. Dwyer AU - M. Vaneckova AU - J. Krasensky AU - J.A. Potts AU - T. Kalincik AU - E. Havrdová AU - D. Horáková TI - Evolution of Cortical and Thalamus Atrophy and Disability Progression in Early Relapsing-Remitting MS during 5 Years AID - 10.3174/ajnr.A3503 DP - 2013 Oct 01 TA - American Journal of Neuroradiology PG - 1931--1939 VI - 34 IP - 10 4099 - http://www.ajnr.org/content/34/10/1931.short 4100 - http://www.ajnr.org/content/34/10/1931.full SO - Am. J. Neuroradiol.2013 Oct 01; 34 AB - BACKGROUND AND PURPOSE: Pathologic changes in GM have an important role in MS. We investigated the association between SDGM and cortical volume changes and disability progression in early RRMS. MATERIALS AND METHODS: One hundred eighty patients with RRMS had clinical assessment during 5 years and were divided into those with or without SDP at 5 years by the usual definition in treatment trials. The number of available MR imaging scans at various time points was the following: at baseline, 178; and at 6 months, 172; at 12 months, 175; at 24 months, 155; at 36 months, 160; at 48 months, 158; and at 60 months, 162, respectively. Longitudinal changes in cortical, GM, and WM volume were calculated by using the direct method. RESULTS: At 5 years, 90 patients with RRMS experienced SDP and 90 had stable disease. At baseline, patients with SDP had longer disease duration, greater T2-lesion volume, and smaller whole-brain, WM, cortical, and SDGM volume (P < .01). At 5 years, patients with SDP had significantly greater percentage decreases from baseline compared with those without SDP in the volume of the whole brain (P < .0001), cortex (P = .001), GM (P = .003), and thalamus (P = .01). In patients who developed SDP at 5 years and those who did not, mixed-effect models, adjusted for age, disease duration, and change of the treatment status, showed significant interactions between SDP status at 5 years and changes with time in whole-brain, cortical, lateral ventricle (all P < .001), thalamus (P = .006), and total SDGM (P = .0095) volume. CONCLUSIONS: SDP is associated with progression of cortical, central, and thalamic atrophy in early RRMS during 5 years. ASAAvonex-Steroid-AzathioprineEDSSExpanded Disability Status ScaleGMgray matterRRrelapsing-remittingSDGMsubcortical deep gray matterSDPsustained disability progressionSIENAstructural image evaluation with normalization of atrophy.