%0 Journal Article %A S.W. Hetts %A M. Saeed %A A.J. Martin %A L. Evans %A A.F. Bernhardt %A V. Malba %A F. Settecase %A L. Do %A E.J. Yee %A A. Losey %A R. Sincic %A P. Lillaney %A S. Roy %A R.L. Arenson %A M.W. Wilson %T Endovascular Catheter for Magnetic Navigation under MR Imaging Guidance: Evaluation of Safety In Vivo at 1.5T %D 2013 %R 10.3174/ajnr.A3530 %J American Journal of Neuroradiology %P 2083-2091 %V 34 %N 11 %X BACKGROUND AND PURPOSE: Endovascular navigation under MR imaging guidance can be facilitated by a catheter with steerable microcoils on the tip. Not only do microcoils create visible artifacts allowing catheter tracking, but also they create a small magnetic moment permitting remote-controlled catheter tip deflection. A side product of catheter tip electrical currents, however, is the heat that might damage blood vessels. We sought to determine the upper boundary of electrical currents safely usable at 1.5T in a coil-tipped microcatheter system. MATERIALS AND METHODS: Alumina tubes with solenoid copper coils were attached to neurovascular microcatheters with heat shrink-wrap. Catheters were tested in carotid arteries of 8 pigs. The catheters were advanced under x-ray fluoroscopy and MR imaging. Currents from 0 mA to 700 mA were applied to test heating and potential vascular damage. Postmortem histologic analysis was the primary endpoint. RESULTS: Several heat-mitigation strategies demonstrated negligible vascular damage compared with control arteries. Coil currents ≤300 mA resulted in no damage (0/58 samples) compared with 9 (25%) of 36 samples for > 300-mA activations (P = .0001). Tip coil activation ≤1 minute and a proximal carotid guide catheter saline drip > 2 mL/minute also had a nonsignificantly lower likelihood of vascular damage. For catheter tip coil activations ≤300 mA for ≤1 minute in normal carotid flow, 0 of 43 samples had tissue damage. CONCLUSIONS: Activations of copper coils at the tip of microcatheters at low currents in 1.5T MR scanners can be achieved without significant damage to blood vessel walls in a controlled experimental setting. Further optimization of catheter design and procedure protocols is necessary for safe remote control magnetic catheter guidance. CCAcommon carotid arteryECAexternal carotid arteryiMRIinterventional MR imagingMARCmagnetically assisted remote controlRFradio-frequencySSFPsteady-state free precession. %U https://www.ajnr.org/content/ajnr/34/11/2083.full.pdf