TY - JOUR T1 - An Expanded Role for Neuroimaging in the Evaluation of Memory Impairment JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 2075 LP - 2082 DO - 10.3174/ajnr.A3644 VL - 34 IS - 11 AU - R.S. Desikan AU - M.S. Rafii AU - J.B. Brewer AU - C.P. Hess Y1 - 2013/11/01 UR - http://www.ajnr.org/content/34/11/2075.abstract N2 - SUMMARY: Alzheimer disease affects millions of people worldwide. The neuropathologic process underlying this disease begins years, if not decades, before the onset of memory decline. Recent advances in neuroimaging suggest that it is now possible to detect Alzheimer-associated neuropathologic changes well before dementia onset. Here, we evaluate the role of recently developed in vivo biomarkers in the clinical evaluation of Alzheimer disease. We discuss how assessment strategies might incorporate neuroimaging markers to better inform patients, families, and clinicians when memory impairment prompts a search for diagnosis and management options. ADAlzheimer diseaseAPOE ε4apolipoprotein ε4FTDfrontotemporal dementiaMCImild cognitive impairmentNFTsneurofibrillary tanglesPIBPittsburgh Compound-BvMRIvolume-based MR imaging; amyloid-β Aβ ER -