TY - JOUR T1 - Evaluation of Diffusivity in the Anterior Lobe of the Pituitary Gland: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 95 LP - 98 DO - 10.3174/ajnr.A3620 VL - 35 IS - 1 AU - A. Hiwatashi AU - T. Yoshiura AU - O. Togao AU - K. Yamashita AU - K. Kikuchi AU - K. Kobayashi AU - M. Ohga AU - S. Sonoda AU - H. Honda AU - M. Obara Y1 - 2014/01/01 UR - http://www.ajnr.org/content/35/1/95.abstract N2 - BACKGROUND AND PURPOSE: 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation is a non–echo-planar technique for DWI, which enables high-resolution DWI without field inhomogeneity–related image distortion. The purpose of this study was to evaluate the feasibility of diffusion-sensitized driven-equilibrium turbo field echo in evaluating diffusivity in the normal pituitary gland. MATERIALS AND METHODS: First, validation of diffusion-sensitized driven-equilibrium turbo field echo was attempted by comparing it with echo-planar DWI. Five healthy volunteers were imaged by using diffusion-sensitized driven-equilibrium turbo field echo and echo-planar DWI. The imaging voxel size was 1.5 × 1.5 × 1.5 mm3 for diffusion-sensitized driven-equilibrium turbo field echo and 1.5 × 1.9 × 3.0 mm3 for echo-planar DWI. ADCs measured by the 2 methods in 15 regions of interests (6 in gray matter and 9 in white matter) were compared by using the Pearson correlation coefficient. The ADC in the pituitary anterior lobe was then measured in 10 volunteers by using diffusion-sensitized driven-equilibrium turbo field echo, and the results were compared with those in the pons and vermis by using a paired t test. RESULTS: The ADCs from the 2 methods showed a strong correlation (r = 0.79; P < .0001), confirming the accuracy of the ADC measurement with the diffusion-sensitized driven-equilibrium sequence. The ADCs in the normal pituitary gland were 1.37 ± 0.13 × 10−3 mm2/s, which were significantly higher than those in the pons (1.01 ± 0.24 × 10−3 mm2/s) and the vermis (0.89 ± 0.25 × 10−3 mm2/s, P < .01). CONCLUSIONS: We demonstrated that diffusion-sensitized driven-equilibrium turbo field echo is feasible in assessing ADC in the pituitary gland. DSDEdiffusion-sensitized driven-equilibriumEPecho-planarTFEturbo field echo ER -