TY - JOUR T1 - Tumor Consistency of Pituitary Macroadenomas: Predictive Analysis on the Basis of Imaging Features with Contrast-Enhanced 3D FIESTA at 3T JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 297 LP - 303 DO - 10.3174/ajnr.A3667 VL - 35 IS - 2 AU - J. Yamamoto AU - S. Kakeda AU - S. Shimajiri AU - M. Takahashi AU - K. Watanabe AU - Y. Kai AU - J. Moriya AU - Y. Korogi AU - S. Nishizawa Y1 - 2014/02/01 UR - http://www.ajnr.org/content/35/2/297.abstract N2 - BACKGROUND AND PURPOSE: Preoperative evaluation of pituitary macroadenoma tumor consistency is important for neurosurgery. Thus, we aimed to retrospectively assess the role of contrast-enhanced FIESTA in predicting the tumor consistency of pituitary macroadenomas. MATERIALS AND METHODS: Twenty-nine patients with pituitary macroadenomas underwent conventional MR imaging sequences and contrast-enhanced FIESTA before surgery. Two neuroradiologists assessed the contrast-enhanced FIESTA, contrast-enhanced T1WI, and T2WI. On the basis of surgical findings, the macroadenomas were classified by the neurosurgeons as either soft or hard. Finally, Fisher exact probability tests and unpaired t tests were used to compare predictions on the basis of the MR imaging findings with the tumor consistency, collagen content, and postoperative tumor size. RESULTS: The 29 pituitary macroadenomas were classified as either solid or mosaic types. Solid type was characterized by a homogeneous pattern of tumor signal intensity without intratumoral hyperintense dots, whereas the mosaic type was characterized by many intratumoral hyperintense dots on each MR image. Statistical analyses revealed a significant correlation between tumor consistency and contrast-enhanced FIESTA findings. Sensitivity and specificity were higher for contrast-enhanced FIESTA (1.00 and 0.88–0.92, respectively) than for contrast-enhanced T1WI (0.80 and 0.25–0.33, respectively) and T2WI (0.60 and 0.38–0.54, respectively). Compared with mosaic-type adenomas, solid-type adenomas tended to have a hard tumor consistency as well as a significantly higher collagen content and lower postoperative tumor size. CONCLUSIONS: Contrast-enhanced FIESTA may provide preoperative information regarding the consistency of macroadenomas that appears to be related to the tumor collagen content. CEcontrast-enhancedPCCpercentage of collagen contentSIsignal intensity ER -