RT Journal Article
SR Electronic
T1 MR Evaluation of Early Myelination Patterns in Normal and Developmentally Delayed Infants
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 69
OP 76
VO 9
IS 1
A1 Rosalind B. Dietrich
A1 William G. Bradley
A1 Edward J. Zaragoza IV
A1 Ronald J. Otto
A1 Ricky K. Taira
A1 Gabriel H. Wilson
A1 Hooshang Kangarloo
YR 1988
UL http://www.ajnr.org/content/9/1/69.abstract
AB This study demonstrates the ability of MR imaging to show progression of myelination in 64 infants and young children (ages 4 days to 36 months). T2-weighted spin-echo pulse sequences, frequently used for routine screening of intracranial disease, were used. Gray-white matter differentiation was seen in all patients, and changes occurring with age were documented. Three distinct patterns were seen, and age ranges were established for each pattern in developmentally normal children: (1) infantile (birth–6 months); (2) isointense (8–12 months); and (3) early adult (10 months onward). There was a statistically significant difference between the age ranges of the normal and developmentally delayed children showing all three patterns. These data should be helpful for identifying and following sequentially both infants with clinically suspected developmental delay and those with dysmyelinating or demyelinating disease.