RT Journal Article
SR Electronic
T1 Magnetic Resonance Imaging of Multiple Sclerosis: A Study of Pulse-Technique Efficacy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 691
OP 702
VO 5
IS 6
A1 Val M. Runge
A1 Ann C. Price
A1 Howard S. Kirshner
A1 Joseph H. Allen
A1 C. Leon Partain
A1 A. Everette James, Jr.
YR 1984
UL http://www.ajnr.org/content/5/6/691.abstract
AB Forty-two patients with the clinical diagnosis of multiple sclerosis were examined by proton magnetic resonance imaging (MRI) at 0.5 T. An extensive protocol was used to facilitate a comparison of the efficacy of different pulse techniques. Results were also compared in 39 cases with high-resolution x-ray computed tomography (CT). MRI revealed characteristic abnormalities in each case, whereas CT was positive in only 15 of 33 patients. Milder grades 1 and 2 disease were usually undetected by CT, and in all cases, the abnormalities noted on MRI were much more extensive than on CT. Cerebral abnormalities were best shown with the T2-weighted spin-echo sequence (TE/TR = 120/1000); brainstem lesions were best defined on the inversion-recovery sequence (TE/TI/TR = 30/400/1250). Increasing TE to 120 msec and TR to 2000 msec heightened the contrast between normal and abnormal white matter. However, the signal intensity of cerebrospinal fluid with this pulse technique obscured some abnormalities.